supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago
supplement:
Folic Acid
supplement:
S-Adenosylmethionine
Research Papers that Mention the Interaction
“High folic acid concentrations (20 and 40 μmol/L) increased SAM :SAH ratios and cell viability.”
Folic acid inhibits tau phosphorylation through regulation of PP2A methylation in SH-SY5Y cells“Rather, FA may disturb physiological regulation of intracellular 1C metabolism by interfering with SAM ’s inhibitory effect on MTHFR activity.”
“Moreover, the production of S-adenosylmethionine (SAM), essential for normal DNA methylation and gene expression, is dependent on folic acid.”
DNA stability and genomic methylation status in colonocyte isolated from methyl-donor-deficient rats“ Folic acid administration also induced a higher (P < 0.01) S-adenosylmethionine : S-adenosylhomocysteine value due to increased S-adenosylmethionine synthesis (P < 0.01).”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback