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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Folic Acid
drug:
Pyrimethamine
Research Papers that Mention the Interaction
“The activity of pyrimethamine against Kenyan strains M24 and K39 is reduced 10-12-fold by 10(-5) mol/L of FA , and virtually eliminated by 10(-5) mol/L of FNA.”
The antimalarial triazine WR99210 and the prodrug PS-15: folate reversal of in vitro activity against Plasmodium falciparum and a non-antifolate mode of action of the prodrug.“The application of folic acid FA ) in newborns treated with PYR decreased the severity of the problem (p < 0.05).”
Effect of pyrimethamine treatment on male rat testicular cell population development“Oral co-administration of folic acid (pteroylglutamic acid, PteGlu) potentiates the decrease of plasma 5-methyltetrahydrofolic acid (5-CH3-H4PteGlu) concentration induced by pyrimethamine ( PYR ) in rats.”
“The bile secretion of reduced folates increased drastically after the administration of PteGlu alone, but not after the administration of PteGlu with PYR.”
“These results show that the concomitant gavage dosing of FA augments PYM embryotoxicity.”
“Low level antagonism of pyrimethamine resulted from the inclusion of p-aminobenzoic acid, p-aminobenzoylglutamic acid or folic acid in the test medium.”
“ Folic acid added to this medium at a physiological concentration of 0.01 mg/liter caused a 1,000-fold reduction in sulfadoxine activity; a 100-fold higher concentration of folic acid caused a 10-fold reduction in pyrimethamine activity.”
“Efforts were directed toward the synthesis of long-acting antimalarials possessing a different mode of action from DHT or pyrimethamine , both of which apparently inhibit the conversion of folic acid to folinic acid9.”
“Aminopterin and pyrimethamine reversibly inhibit the enzyme folic acid reductase which catalyses the reduction of folic acid to tetrahydrofolic acid.”
“Cook2found that in mouse mince-tissue cultures folic acid antagonized the antitoxoplasmal activity of pyrimethamine when the vitamin was present in concentrations eight times that of the drug.”
EXPERIMENTAL USE OF FOLINIC ACID IN THE TREATMENT OF TOXOPLASMOSIS WITH PYRIMETHAMINE.“In Streptococcus faecalis the inhibition by pyrimethamine is reversed only at low concentrations by folic acid ; citrovorum factor was much more effective as a reversing agent (4).”
“In addition, the effect of pyrimethamine on the synthesis of folic acid from p-aminobenzoic acid has been invcstigatrd.”
“It has been demonstrated that pyrimethamine is a potent inhibitor of the conversion of folic acid to citrovorum factor in these systems.”
“ Pyrimethamine is one of a series of 2,4-diaminopyrimidines which have been shown to be antagonists of folic acid and citrovorum factor (formyltetrahydrofolic acid) for the growth of Lactobacillus casei (4).”
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