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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Folic Acid
drug:
Probenecid
Research Papers that Mention the Interaction
“Consequently, CEM-7A cells displayed a 5-fold decrease in the [3H]folic acid efflux rate constant, which was identical to that obtained with parental CEM cells, when their folic acid efflux was blocked (78%) with probenecid.”
Loss of Multidrug Resistance Protein 1 Expression and Folate Efflux Activity Results in a Highly Concentrative Folate Transport in Human Leukemia Cells*“Membrane transport inhibitors SITS, DIDS, probenecid and endocytic inhibitor, colchicine significantly inhibited the [3H]folic acid uptake indicating the involvement of receptor/transporter mediated process.”
Functional Characterization of Folate Transport Proteins in Staten’s Seruminstitut Rabbit Corneal Epithelial Cell Line“ Probenecid decreased the level of uptake of radiolabeled folic acid , suggesting a transport-based mechanism linked to folate salvage.”
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