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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Folic Acid
drug:
Phenytoin
Research Papers that Mention the Interaction
“More cases (93 percent) in group II exhibited minimal overgrowth as against 78 percent in group I. The study concluded that systemic folic acid prescribed along with phenytoin delays the onset and reduces the incidence and severity of gingival overgrowth induced by phenytoin.”
Folic acid and phenytoin induced gingival overgrowth--is there a preventive effect.“Supplementation with folic acid prevents deficiency but also changes PHT pharmacokinetics.”
“This study suggests an interdependence between PHT and folic acid and supports the observation that fertile women treated with PHT require folic acid supplementation to maintain a normal serum folate level.”
“Significant decreases in mean serum and CSF phenobarbital and diphenylhydantoin concentrations were found in the folic acid treated subjects.”
“The activation of HGFs by phenytoin was markedly reduced in the presence of antioxidant vitamins: ascorbic acid, folic acid , and α-tocopherol.”
“In mice, the dysmorphogenic effect of phenytoin is day and dose dependent and may be partially prevented by the administration of folic acid supplements.”
“Among the potential safety issues are interaction between folic acid and zinc, interaction between folic acid and drugs ( phenytoin , methotrexate etc.)”
“Folic acid tolerance tests performed at 0, 4, 12, 16 and 20 hours after diphenylhydantoin showed a progressive rise in serum levels as diphenylhydantoin was withheld for longer periods prior to the test dose of folic acid.”
“Conclusions: Oral folic acid was found to decrease the incidence of PIGO in children on PHT monotherapy, in a statistically significant and clinically relevant manner.”
“BackgroundAntiepileptic drugs (AEDs) like phenytoin (PHE), carbamazepine (CBZ), barbiturates and valproic acid (VPA) interfere with folic acid absorption and metabolism, which in turn can be the cause of adverse pregnancy outcome.”
“Patients receiving phenytoin had significantly lower folic acid levels and those receiving carbamazepine had marginally lower pyridoxal 5'-phosphate levels in comparison with those using other anti-epileptic drugs.”
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