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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Folic Acid and Phenytoin

supplement:

Folic Acid

Research Papers that Mention the Interaction

More cases (93 percent) in group II exhibited minimal overgrowth as against 78 percent in group I. The study concluded that systemic folic acid prescribed along with phenytoin delays the onset and reduces the incidence and severity of gingival overgrowth induced by phenytoin.
Journal of the Indian Society of Pedodontics and Preventive Dentistry  •  2004  |  View Paper
Supplementation with folic acid prevents deficiency but also changes PHT pharmacokinetics.
This study suggests an interdependence between PHT and folic acid and supports the observation that fertile women treated with PHT require folic acid supplementation to maintain a normal serum folate level.
Journal of the American Dietetic Association  •  1995  |  View Paper
Significant decreases in mean serum and CSF phenobarbital and diphenylhydantoin concentrations were found in the folic acid treated subjects.
Archives of neurology  •  1973  |  View Paper
The activation of HGFs by phenytoin was markedly reduced in the presence of antioxidant vitamins: ascorbic acid, folic acid , and α-tocopherol.
Journal of dental research  •  2017  |  View Paper
In mice, the dysmorphogenic effect of phenytoin is day and dose dependent and may be partially prevented by the administration of folic acid supplements.
Drugs  •  2012  |  View Paper
Among the potential safety issues are interaction between folic acid and zinc, interaction between folic acid and drugs ( phenytoin , methotrexate etc.)
Praxis  •  2002  |  View Paper
Folic acid tolerance tests performed at 0, 4, 12, 16 and 20 hours after diphenylhydantoin showed a progressive rise in serum levels as diphenylhydantoin was withheld for longer periods prior to the test dose of folic acid.
Blood  •  1967  |  View Paper
Conclusions: Oral folic acid was found to decrease the incidence of PIGO in children on PHT monotherapy, in a statistically significant and clinically relevant manner.
Neurology  •  2011  |  View Paper
BackgroundAntiepileptic drugs (AEDs) like phenytoin (PHE), carbamazepine (CBZ), barbiturates and valproic acid (VPA) interfere with folic acid absorption and metabolism, which in turn can be the cause of adverse pregnancy outcome.
Journal of Neurology  •  2008  |  View Paper
Patients receiving phenytoin had significantly lower folic acid levels and those receiving carbamazepine had marginally lower pyridoxal 5'-phosphate levels in comparison with those using other anti-epileptic drugs.
Seizure  •  2006  |  View Paper
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