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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Folic Acid
drug:
Phenobarbital
Research Papers that Mention the Interaction
“It is concluded that folic acid partially reverses both the therapeutic (antiepileptic) and retarding effects of phenobarbitone , phenytoin, and primidone.”
Effects of folic acid on the mental state and fit-frequency of drug-treated epileptic patients.“The possible mechanisms by which phenobarbitone might interfere with the synthesis of pteroylpolyglutamates, the actual coenzymic forms of folic acid , are discussed.”
Pteroylpolyglutamates in liver of phenobarbitone-treated rats.
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