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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Folic Acid
drug:
Nitric Oxide
Research Papers that Mention the Interaction
“In vitro, folic acid directly increases nitric oxide (NO) production and extends its duration of action; effects which could be of benefit in reversing pulmonary hypertension and severe hypoxaemia.”
“Our work has shown that, in the systemic circulation, folic acid in high dose rapidly improves nitric oxide mediated vasodilation, by activating endothelial nitric oxide synthase (eNOS).”
High dose folic acid is a potential treatment for pulmonary hypertension, including when associated with COVID-19 pneumonia“In CoCl2-treated HUVECs, folic acid significantly attenuated PGE2 production and increased vasoprotective nitric oxide ( NO ) content.”
“Research should be undertaken to examine whether folic acid negatively impacts NO and attention-related neurotransmitters in the brain in such a way as to induce ADHD-I symptoms.”
“…,FA was found to significantly increase the …<0.05 vs. control) and NO production (37.86±12.34 nmol/l, 38.45±11.23 nmol/l vs 26.21±9.24 ….87±26.76 nmol/l vs. 165.23±30.56 nmol/l; P<0.05 vs. Hcy group).”
“TNF-α and IL-1β, as well as iNOS dependent NO production, resulted significantly inhibited by folic acid pretreatment in LPS-activated BV-2 cells.”
Folic Acid Is Able to Polarize the Inflammatory Response in LPS Activated Microglia by Regulating Multiple Signaling Pathways“Interestingly, FO+FA not only offered significant protection against NPA-induced behavioural impairments, but also markedly attenuated oxidative stress in brain regions (striatum/cerebellum) as evidenced by the reduction in reactive species, malondialdehyde, hydroperoxides and nitric oxide (NO) levels.”
“Furthermore, live LcZ significantly suppresses polyinosinic:polycytidylic acid (poly I:C)‐stimulated NO , iNOS and TNF‐α expression while enhancing expression of IFN‐β.”
“After LPS stimulation, ω-3 FA pretreatment at 12 and 24 h produced significantly less NO (P < 0.05) compared with ω-6 FA or media only.”
“Pretreatment with LcZ also markedly reduced LPS/D-GalN-induced production of hepatic nitric oxide (NO), activation of inducible nitric oxide synthase (iNOS) and expression of tumor necrosis factor-α (TNF-α).”
“Together the results suggest that the antidepressant-like effect of folic acid in the forced swimming test is dependent on an inhibition of either NMDA receptors or NO and cGMP synthesis.”
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