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Discover Supplement-Drug Interactions

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Last Updated: 3 months ago

Possible Interaction: Folic Acid and Methotrexate

supplement:

Folic Acid

Research Papers that Mention the Interaction

OBJECTIVES This study investigated whether: (i) rheumatoid arthritis (RA) patients have more micronuclei (MN) than healthy controls; (ii) methotrexate (MTX) treated RA patients have more MN than those not using MTX, and (iii) folic acid supplementation decreases the number of MN in MTX treated patients.
Clinical and experimental rheumatology  •  2002  |  View Paper
Supplementation with folic or folinic acid reduced the risk of toxicity-related discontinuation of MTX treatment both in patients with and in patients without the mutation.
Arthritis and rheumatism  •  2001  |  View Paper
These results reopen the question of whether folic acid should be used immediately in all patients when MTX is begun.
Total clearance of MTX and Vd were higher when patients were also receiving folic acid than when they were taking MTX alone (p < 0.02).
The Journal of rheumatology  •  2000  |  View Paper
Folic acid supplementation has been reported anecdotally to lessen toxicity in patients receiving methotrexate treatment [27, 28].
The influence of the folic acid dose on methotrexate toxicity and efficacy remains controversial, and the effects of different doses of folic acid are not known [37, 38].
Annals of Internal Medicine  •  1994  |  View Paper
Interestingly, the induction of different sulfotransferases by MTX was inhibited by high doses of folic acid at both protein and mRNA levels in Hep G2 cells.
Journal of applied toxicology : JAT  •  2005  |  View Paper
Inhibition studies of human rNAT1 and hamster rNAT2 revealed that folic acid and methotrexate ( MTX ) are competitive inhibitors of both the unacetylated and acetylated forms of the enzymes, with KI values in 50–300 μ range.
The protein journal  •  2005  |  View Paper
MTX , an antagonist of folic acid synthesis, causes apoptosis in activated cells, primarily in the G1 and S phases of the cell cycle.
Postepy higieny i medycyny doswiadczalnej  •  2004  |  View Paper
Among the potential safety issues are interaction between folic acid and zinc, interaction between folic acid and drugs (phenytoin, methotrexate etc.)
Praxis  •  2002  |  View Paper
This was true for all methotrexate concentrations examined from 10 μM to 3 mM. The presence of folic acid at concentrations above 0.1 mM and of acidic conditions decreased the uptake of methotrexate into single cells and enhanced tissue penetration.
International journal of cancer  •  2001  |  View Paper
In addition, RA patients with the MTHFR C677T polymorphism who were supplemented with folic acid displayed significantly elevated risk for MTX toxicity.
Genetic testing and molecular biomarkers  •  2017  |  View Paper
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