Possible Interaction: Folic Acid and Methionine

“One therapeutic approach for tHcy reduction is vitamine supplementation, since folic acid and cobalamine catalyse and enhance metabolism of tHcy to methionine.”

“We conclude that folic acid supplementation effectively prevented atherosclerosis by modifying DNA methylation through the methionine cycle , improving DNA methyltransferase activity and expression, and thus changing the expression of atherosclerosis-related genes.”

“These observations suggest that folic acid supplementation may enhance cellular methylation capacity under a low methionine status.”

“Evidence suggests that methionine interacts with folic acid and vitamin B(12) in the methylation of contractile proteins involved in closing the neural folds.”

“ Folic acid treatment increased the homocysteine remethylation rate by 59% [95% CI (confidence interval), 13-97%; P = 0.02] and methionine transmethylation rate by 20% (95% CI, 3-41%; P=0.03).”

“We propose that folic acid in excess acts by enhancing the remethylation of homocysteine to methionine.”

“Treatment (Betaine, folic acid , vitamin B 12) induced the disappearance of plasma methionine.”

“ Folic acid therapy resulted in substantial reductions (n = 15, P less than 0.01) of MDS concentrations both before the methionine load (-31%) and after (-28%), though subjects had initially had normal concentrations of serum and erythrocyte folates.”

“This explains why administration of folic acid , which induces cell division and use of methionine in protein synthesis, impairs methylation of myelin and precipitates or exacerbates subacute combined degeneration (SCD).”

“Neural differentiation was inhibited below 0.007 mM and above 0.22 mM FA , while both stem cell viability (< 0.097 mM, > 1.52 mM) and neural differentiation (< 0.181 mM, > 1.35 mM) were affected when changing MET concentrations.”