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Discover Supplement-Drug Interactions

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Last Updated: 5 months ago

Possible Interaction: Folic Acid and Memantine


Folic Acid

Research Papers that Mention the Interaction

Increased levels of FA at 1000 μM in combination with 20 μM Mn exerted an additive protection against Aβ(25-35)-induced-apoptosis as compared to the isolate Mn group (P<0.05).
Taken together, the data demonstrated that dose-dependent FA and Mn synergistically or additively protected SH-SY5Y cells against Aβ-induced apoptosis, which was partially, if not completely, mediated by mt stress-associated death signals.
This study investigated whether and the underlying mechanisms by which the combination of Mn and FA may have synergistic or additive effects in protecting against amyloid-β(25-35) peptide (Aβ)-induced neurocytotoxicity.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association  •  2013  |  View Paper
In conclusion, we found that folic acid may potentiate the effect of memantine on spatial learning and neuronal protection.
We propose that folic acid might have a synergistic effect for memantine in protecting neurons from Abeta accumulation.
Journal of Alzheimer's disease : JAD  •  2010  |  View Paper