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Discover Supplement-Drug Interactions

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Last Updated: 5 months ago

Possible Interaction: Folic Acid and Memantine

supplement:

Folic Acid

Research Papers that Mention the Interaction

Increased levels of FA at 1000 μM in combination with 20 μM Mn exerted an additive protection against Aβ(25-35)-induced-apoptosis as compared to the isolate Mn group (P<0.05).
Taken together, the data demonstrated that dose-dependent FA and Mn synergistically or additively protected SH-SY5Y cells against Aβ-induced apoptosis, which was partially, if not completely, mediated by mt stress-associated death signals.
This study investigated whether and the underlying mechanisms by which the combination of Mn and FA may have synergistic or additive effects in protecting against amyloid-β(25-35) peptide (Aβ)-induced neurocytotoxicity.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association  •  2013  |  View Paper
In conclusion, we found that folic acid may potentiate the effect of memantine on spatial learning and neuronal protection.
We propose that folic acid might have a synergistic effect for memantine in protecting neurons from Abeta accumulation.
Journal of Alzheimer's disease : JAD  •  2010  |  View Paper