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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Folic Acid
drug:
Lometrexol
Research Papers that Mention the Interaction
“Preclinical murine studies demonstrated that the toxicity of lometrexol can be prevented by low dose folic acid administration, i.e. for 7 days prior to and 7 days following a single bolus dose.”
“This observation prompted a Phase I clinical study of lometrexol given with folic acid supplementation which has confirmed that the toxicity of lometrexol can be markedly reduced by folic acid supplementation.”
A Phase I clinical study of the antipurine antifolate lometrexol (DDATHF) given with oral folic acid“Subsequent preclinical and clinical studies suggested that coadministration of folic acid might favorably modulate lometrexol toxicity without eliminating potential antitumor activity.”
“Optimization of the folic acid content in the diet and of the lometrexol dosage are predicted to have substantial impact on the clinical activity of this class of drugs.”
“Patients received either 5 mg of folic acid 1 h before or 25 mg/m2 3 h before lometrexol.”
“In conclusion, the study highlights the modulation of DDATHF cytotoxicity by folic acid or by folinic acid and provides further rationale for in vivo clinical investigation with these combinations.”
“The cytotoxic potential of DDATHF was modulated by the folic acid concentration present in the medium.”
“In folic acid-containing media , polyglutamation of 5,10-dideazatetrahydrofolate was markedly reduced, yet folylpolyglutamate synthetase activity was not different from that in parental L1210 cells.”
Cellular Folates Prevent Polyglutamation of 5,10-Dideazatetrahydrofolate
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