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Last Updated: 7 months ago

Possible Interaction: Folic Acid and Lometrexol

supplement:

Folic Acid

Research Papers that Mention the Interaction

Preclinical murine studies demonstrated that the toxicity of lometrexol can be prevented by low dose folic acid administration, i.e. for 7 days prior to and 7 days following a single bolus dose.
This observation prompted a Phase I clinical study of lometrexol given with folic acid supplementation which has confirmed that the toxicity of lometrexol can be markedly reduced by folic acid supplementation.
Investigational New Drugs  •  2004  |  View Paper
Subsequent preclinical and clinical studies suggested that coadministration of folic acid might favorably modulate lometrexol toxicity without eliminating potential antitumor activity.
Cancer Chemotherapy and Pharmacology  •  2000  |  View Paper
Optimization of the folic acid content in the diet and of the lometrexol dosage are predicted to have substantial impact on the clinical activity of this class of drugs.
Cancer research  •  1996  |  View Paper
Patients received either 5 mg of folic acid 1 h before or 25 mg/m2 3 h before lometrexol.
Clinical cancer research : an official journal of the American Association for Cancer Research  •  1998  |  View Paper
In conclusion, the study highlights the modulation of DDATHF cytotoxicity by folic acid or by folinic acid and provides further rationale for in vivo clinical investigation with these combinations.
The cytotoxic potential of DDATHF was modulated by the folic acid concentration present in the medium.
British Journal of Cancer  •  1994  |  View Paper
In folic acid-containing media , polyglutamation of 5,10-dideazatetrahydrofolate was markedly reduced, yet folylpolyglutamate synthetase activity was not different from that in parental L1210 cells.
The Journal of Biological Chemistry  •  1998  |  View Paper