supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Folic Acid
drug:
Levoleucovorin
Research Papers that Mention the Interaction
“A relationship of CF to PGA is further indicated by the increased urinary excretion of CF which occurs when PGA is fed (12-16).”
Metabolism of pteroylglutamic acid and the citrovorum factor in patients with scurvy.“Very large doses of citrovorum factor were able to block the inhibitory effect of the folic acid antagonists on formate incorporation in vivo.”
Comparative effect of amethopterin and its 3',5'-dichloro derivative on purine biosynthesis in leukemic mice.“ Citrovorum factor leucovorin, and folinic acid-SF when given in the diet were substantially less active than pteroylglutamic acid.”
“The possibility is considered that the analogues of pteroylglutamic acid interfere with formylation rather than the reduction of pteroylglutamic acid in the biosynthesis of citrovorum factor.”
Chemical and biological studies on 1,2-dihydro-s-triazines“ Citrovorum factor did not influence the growth of resistant leukemic cells but partially blocked the optimal growth-promoting effect of the PGA antagonist.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback