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Last Updated: 2 years ago

Possible Interaction: Folic Acid and Leucovorin

supplement:

Folic Acid

Research Papers that Mention the Interaction

Leucovorin LV ), a reduced folate, was 30-fold more potent than folic acid in promoting growth, whereas the analogous form of DL-e,t-gamma-fluorofolate, DL-e,t-gamma-fluoroleucovorin (DL-e,t-gamma-FLV) was only 4-fold more potent than folic acid.
Biochemical pharmacology  •  1996  |  View Paper
These data indicate that PteGlu and 5-formyltetrahydrofolic acid , which are thought to be well absorbed (about 90 %) at physiological doses, exhibit dramatically different rates and patterns of plasma response.
British Journal of Nutrition  •  2003  |  View Paper
Leucovorin can have clinically important immunologic cross-reactivity with folic acid.
The Journal of allergy and clinical immunology  •  2000  |  View Paper
Folic acid inhibits the metabolism of 5-formyltetrahydrofolic acid in vitro, is contraindicated in some cases of clinical folate deficiency and may be inappropriate in others.
Clinica chimica acta; international journal of clinical chemistry  •  1989  |  View Paper
Citrovorum factor leucovorin, and folinic acid-SF when given in the diet were substantially less active than pteroylglutamic acid.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine  •  1952  |  View Paper