Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 months ago

Possible Interaction: Folic Acid and Leucovorin

supplement:

Folic Acid

Research Papers that Mention the Interaction

These data indicate that PteGlu and 5-formyltetrahydrofolic acid , which are thought to be well absorbed (about 90 %) at physiological doses, exhibit dramatically different rates and patterns of plasma response.
The British journal of nutrition  •  2003  |  View Paper
Leucovorin can have clinically important immunologic cross-reactivity with folic acid.
The Journal of allergy and clinical immunology  •  2000  |  View Paper
Folic acid inhibits the metabolism of 5-formyltetrahydrofolic acid in vitro, is contraindicated in some cases of clinical folate deficiency and may be inappropriate in others.
Clinica chimica acta; international journal of clinical chemistry  •  1989  |  View Paper
Symptoms are ameliorated by therapy with 5-formyltetrahydrofolate but exacerbated by folic acid.
Postgraduate medical journal  •  1986  |  View Paper
A relationship of CF to PGA is further indicated by the increased urinary excretion of CF which occurs when PGA is fed (12-16).
The Journal of clinical investigation  •  1952  |  View Paper
Leuconostoc citrovorum factor … Lactobacillus casei , the two organisms generally used in the microbiological assay of folic acid, and in view of the structural and metabolic similarities of … to the components of the total liberated microbiological activity before further studies could be undertaken on the metabolic functions of these components.
The Journal of biological chemistry  •  1952  |  View Paper
Leucovorin LV ), a reduced folate, was 30-fold more potent than folic acid in promoting growth, whereas the analogous form of DL-e,t-gamma-fluorofolate, DL-e,t-gamma-fluoroleucovorin (DL-e,t-gamma-FLV) was only 4-fold more potent than folic acid.
Biochemical pharmacology  •  1996  |  View Paper
Uptake of 5-FTHF was inhibited by the structural analogs 5-methyltetrahydrofolate, methotrexate and folic acid (K(i)=6.64, 7.69, and 19.38 microM, respectively).
Brain Research  •  2003  |  View Paper
Uptake of 5-FTHF was inhibited by the structural analogs 5-methyltetrahydrofolate, methtrexate, and folic acid (K(i)=3.8, 2.7, and 18.4 microM, respectively).
Archives of biochemistry and biophysics  •  2003  |  View Paper
Very large doses of citrovorum factor were able to block the inhibitory effect of the folic acid antagonists on formate incorporation in vivo .
Cancer research  •  1960  |  View Paper
Show More