Possible Interaction: Folic Acid and Lamotrigine

“ Lamotrigine improved depression, but its effectiveness was reduced by FA.”

“ Folic acid seems to nullify the effect of lamotrigine.”

“There was a significant interaction (p=0·028), with folic acid reducing the effectiveness of lamotrigine at 12 weeks.”

“Because little is known about how folic acid might have interfered with lamotrigine , we believe that these conclusions may be unwarranted, especially when considering alternative folate forms that might be less likely to interact with lamotrigine.”

“The researchers concluded that the combination of lamotrigine and folate should be avoided, and cautioned about the potential eff ect of widespread folic acid fortifi cation on lamotrigine ’s effi cacy.”

“Further, the results clearly demonstrate the additional benefits on epilepsy, mood and memory brought about by the inclusion of FA in the LTG regimen.”

“The combination of LTG and FA significantly reduced depression while enhancing the effects on memory and seizure threshold.”

“Results: The results of the … reveals that teratogenic effects of lamotrigine , methyldopa and loratadine (LTMLO) combination were seems to be reduced upon simultaneous administration with folic acid , while addition of vitamin E was found to be more effective in reducing the mortality rate of levetiracetam, methyldopa and loratadine combination.”