Possible Interaction: Folic Acid and Iron, Dietary

“Anemia in the third trimester was reduced by 54% with folic acid plus iron , by 48% with folic acid plus iron and zinc and by 36% with folic acid plus iron, zinc and multiple micronutrients supplementation, relative to the control (P < 0.05).”

“On the other hand, in the groups given iron alone or iron plus folic acid there was an increase in Hb of 0.4 and 0.7 g/dl, respectively (intergroup difference not statistically significant).”

“In areas where Plasmodium falciparum malaria is holoendemic, universal supplementation of children with iron and folic acid may increase the incidence of severe morbidity and mortality.”

“Although simultaneous supplementation of iron and folic acid is justified, the potential interactions between these micronutrients and other elements are poorly known.”

“In conclusion, simultaneous supplementation of iron and folic acid impairs the level of zinc, calcium, and magnesium in women of childbearing age.”

“BACKGROUND & AIMS Although disorders of iron metabolism are among the most … and dietary intakes of vitamin A, B2, B6, C, E, and folic acid are known to affect … or oxidation of iron , limited data are available on the association of dietary … these vitamins with mortality in the same population.”

“Background Undesirable effects of a daily regimen of iron and folic acid ingested jointly (iron-folate) are potential disincentives to optimal antenatal supplementation.”

“Conclusions The commonness of undesirable experiences attributed to daily ingestion of 60 mg iron and 0.4 mg folic acid and their deterrence to longer supplementation durations suggest the need for considering a weekly intermittent regimen for some antenatal women in such set-ups.”

“Children in which mothers used both iron and folic acid supplementation had a fourfold decreased risk of developing atopic dermatitis [OR = 0.22; 95% confidence interval (CI) 0.06–0.79, p = 0.02], after adjusting for possible confounding factors.”

“A positive correlation has been revealed between the concentration of folic acid and the level of HDL-C (r=0.356, p<0.01), and iron (r=0.378, p<0.05).”

“In MINIMat, EMMS significantly reduced IM compared to UFe60F (U plus 60 mg iron 400 μgm Folic acid).”

“Adding iron to folic acid for periconceptional use may improve iron status but is not likely to prevent NTDs.”