Possible Interaction: Folic Acid and Homocysteine

“Daily consumption of fortified milk powder providing 375 microg folic acid increases blood folate and lowers homocysteine concentrations over 12 weeks in women of childbearing age.”

“ABSTRACT Background: Increased plasma homocysteine (Hcy) levels are a risk factor for stroke and can be reduced with folic acid therapy.”

“With supplementation of both folic acid and vitamin B12, the levels of ADMA and Hcy decreased significantly at 2 and 12 weeks (p<0.05).”

“ Folic acid and folinic acid decreased the blood homocysteine levels by 33.0% and 28.7%, respectively (P < .001).”

“Objective: Folic acid (FA) supplementation decreases homocysteine (tHcy) levels.”

“In patients with chronic renal failure, the administration of folic acid or its metabolites reduces but does not normalize plasma homocysteine concentrations.”

“One therapeutic approach for tHcy reduction is vitamine supplementation, since folic acid and cobalamine catalyse and enhance metabolism of tHcy to methionine.”

“Plasma total homocysteine tHcy ) concentrations are markedly increased in end-stage renal disease and only partially corrected by folic acid supplementation.”

“CONCLUSIONS These results show that fo ic acid su pplementation lowers plasma Hcy le vels and improves insulin and lipid metabolism, reducing the risk of cardiovascular disease.”

“…,tHcy concentration … folic acid and B12 intakes in untrained (r = –0.589, p < 0.05; r = –0.580, p < 0.05, respectively) as well as in trained …, p < 0.01; r = –0.731, p < 0.01, respectively) whereas no correlation between tCys and vitamin in the diet was observed.”