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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Folic Acid
Research Papers that Mention the Interaction
“Varying the medium folic acid (PteGlu) concentration over the range of 0.5 to 100 microM increasingly blocks the growth inhibitory effects of the individual antifolates in Manca human lymphoma cells, but increasingly enhances the synergistic interaction of both TMTX + DDATHF and TMTX+ PDDF combinations.”
Quantitation of folic acid enhancement of antifolate synergism.“The reduction in cellular folates caused by growth in nM folic acid caused enhanced growth inhibitory activity of several antifolates.”
The characteristics and consequences of folate depletion in hepatoma cells in vitro by inhibition of dihydrofolate reductase.“The observation that azide enhances net MTX uptake in resistant as well as sensitive L5178Y cells along with … the net uptake of folic acid is enhanced by azide raises the possibility that the effects of metabolic inhibitors on … folic acid may be mediated, at least … a common exit process.”
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