Possible Interaction: Folic Acid and Folate

“ Folic acid increased plasma folate (P <0.001), lowered homocysteine by 19% (P <0.001), and improved FMD (P <0.001).”

“We conclude that although folic acid supplementation in nonpregnant women increases RBC total folate and the concentration of individual folate forms, it does not alter the relative distribution of folate forms.”

“Red blood cell folate level increased after folic acid supplementation.”

“Results: FA supplementation induced a decrease in tHcy (from 51.1 ± 21 at baseline to 26.1 ± 27 μmol/L after folate supplementation; p < 0.01).”

“…:Folic acid supplementation increased … and erythrocyte folate concentrations by 81% (95% confidence interval (CI) 57–104%; p<0.001 v placebo) and 57% (95% CI 40–74%; p<0.001 v placebo), respectively, and decreased plasma homocysteine concentration by 12% (95% CI 4–20%; p = 0.01 v placebo).”

“ Folic acid increased serum folate by 14 nmol/L (6.2 ng/mL, P<.001) and RCF by 467.2 nmol/L (206 ng/mL, P<.001).”

“Concomitant folate supplementation with either folic or folinic acid decreases the plasma homocysteine level and consequently protects against potential cardiovascular risks.”

“CONCLUSIONS A folate-rich diet including fo ic ac id-fortified foods or low-dose supplements effectively increases fol ate st atus.”

“In subjects who consumed folic acid-fortified breakfast cereal, folate intake increased by an average of 298 microg, serum folate increased by 21 nmol/L, and tHcy concentrations decreased by 24%.”

“ Folic acid plus antioxidants increased plasma folate by 438% (p < 0.001), reduced plasma homocysteine by 9% (p = 0.56) and insignificantly improved FMD from 2.6 +/- 2.4% to 4.0 +/- 3.7% (p = 0.45), as compared with placebo.”