Possible Interaction: Folic Acid and Doxorubicin Hydrochloride

“Moreover, the pH responsive release behaviors of DOX are controlled by FA.”

“The selective cytotoxicity of hollow silica nanoparticles was further enhanced by conjugation of folic acid and incorporation of DOX : at 24h and an equivalent DOX concentration of 0.5 μg mL(-1), viable Caco2 cells were reduced to 45% while 3T3 cells were reduced to 83%.”

“It was found that the cellular uptake of DOX increased 15.2% by TPGS conjugation and further 6.3% by FOL conjugation after 0.5-h cell culture.”

“The results showed that the nanocarrier of FA-BO-PAMAM was successfully synthesized, which was spherical in morphology with the average size of (22.… the cytotoxicity of PAMAM against both HBMEC and C6 cells and exhibited higher BBB transportation ability than BO-unmodified conjugates; moreover, modification with FA … DOX ….”

“The KB cellular association of F–PLL-coated liposomal DXR was increased compared with that of PLL-coated liposomes and was inhibited in the presence of free folic acid.”

“In this study we discovered that the cytotoxicity and fluorescence of doxorubicin are quenched (OFF) when covalently linked with folic acid.”

“ Folic acid magnetic nanotheranostic reduced the toxicity caused by Doxorubicin.”

“It can be concluded from the FE calculations that while the FA is stuck on the substrate, DOX faces difficulty in the way it be adsorbed.”

“We attributed this effect to the quenching of Dox by FA and herein investigate this phenomenon in an attempt to obtain a correction factor that could be applied to the fluorescence of Dox in the presence of FA.”