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Discover Supplement-Drug Interactions

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Last Updated: 3 months ago

Possible Interaction: Folic Acid Antagonists and Homocysteine

Research Papers that Mention the Interaction

This study points out for the first time the importance of pretreatment tHcy levels in predicting severe toxicity associated with an antifolate and sets the stage for a prospective clinical intervention to protect patients from pemetrexed-induced severe toxicity and possibly improve the drug's efficacy.
Molecular cancer therapeutics  •  2002  |  View Paper
However, combined culture of the NMDA antagonist , MK-801, with homocysteine did enhance intracellular Ca(2+) levels.
European journal of pharmacology  •  2016  |  View Paper
L-homocysteine (50 μM) induced inward currents that were completely blocked by the selective antagonist of NMDA receptors, AP-5.
Journal of Evolutionary Biochemistry and Physiology  •  2015  |  View Paper
When cells were treated with homocysteine- or glutamate in the presence of MK-801, an antagonist of the N-methyl-D-aspartate (NMDA) receptor, the cell death was inhibited significantly.
Brain research. Molecular brain research  •  2004  |  View Paper
One potentially important consequence of this putative mechanism is that homocysteine may interact synergistically with other NMDAR antagonists to enhance its effect on development.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology  •  1999  |  View Paper
Under control conditions, responses to glutamate resembled responses to quisqualate, and were relatively insensitive to CNQX, 3-((+/-)-2-carboxypiperazin-4-yl)-propyl-l-phosphonic acid and 2-amino-5-phosphonovalerate, while responses to homocysteic acid resembled responses to NMDA and were blocked by these antagonists.
Neuroscience  •  1990  |  View Paper
The antagonists non-selectively reduced the excitatory responses evoked by 5-HT, 5-CT, alpha-Me-5-HT, D, L-homocysteic acid (DLH) and noradrenaline (NA).
British journal of pharmacology  •  1990  |  View Paper
We also show that known NMDA antagonists , including Mg++, D-aminophosphonopentanoate and certain anesthetics, analgesics, and sedative hypnotics block the neurotoxic actions of L-HCA in direct proportion to their efficacy in blocking NMDA neurotoxicity.
Brain Research Bulletin  •  1987  |  View Paper