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Discover Supplement-Drug Interactions

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Last Updated: 3 months ago

Possible Interaction: Folic Acid Antagonists and Glutathione

Research Papers that Mention the Interaction

CONCLUSION Inhibition of Glu and Cys uptake by EAAT and Xc(-) exchanger antagonists depletes GSH in human lens epithelial cells.
EAAT and Xc(-) exchanger inhibition by substrate antagonists depleted GSH concentrations by 15-28% (p's ≤ 0.02), while GSH synthesis inhibition by buthionine sulfoximine depleted GSH by 33% (p = 0.008).
Current eye research  •  2016  |  View Paper
The role of glutathione in modulating the malaria parasite's response to antifolates suggests that development of specific inhibitors against Plasmodium γ-GCS may offer a new approach to counter Plasmodium antifolate resistance.
Antimicrobial Agents and Chemotherapy  •  2016  |  View Paper
GSH levels can be reduced by cell growth in the presence of an analog of gamma glutamyl, alpha-aminobutyrate, L-buthionine (S/R) sulfoximine (L-BSO).
Biochemical and biophysical research communications  •  1987  |  View Paper