Possible Interaction: Folic Acid Antagonists and Folate

“However, the concomitant use of folate and antifolate is associated with a decrease in antifolate efficacy, exposing pregnant women to malaria.”

“ Folate depletion increased the sensitivity of these cell lines to antifolates and EGCG.”

“Poly(gamma-glutamylation) of glutamate (L-Glu)-containing antifolates and natural folates is important in pharmacological mechanisms and in physiological processes.”

“Despite studies showing folate depletion during antifolate chemotherapy and higher toxicity of chemotherapy in folate-depleted individuals, folate supplementation during cancer chemotherapy is not routinely recommended.”

“ Antifolates inhibit de novo folate biosynthesis, whereas ethionamide targets the mycolate synthetic pathway in Mycobacterium tuberculosis.”

“Patients with higher folate intake may experience less treatment-related toxicities; however, the concern is that folate may interfere with the effectiveness of the antifolate treatment and possibly support tumor growth.”

“Newer antifolates have been described that inhibit more than one pathway in folate metabolism, that have improved delivery, or that inhibit other targets in folate metabolism.”

“The dramatic intensity of the synergism between DDATHF and TMTX at 40 microM PteGlu, along with the concept of modulation of antifolate synergism by folates , suggests future in vivo and/or clinical applications of combinations of these (or similar) compounds.”

“These results indicate that the nature of the membrane transport system for folates can be a critical determinant in tumor cell sensitivity or resistance to antifolates.”

“Supplementation of culture medium with folate markedly antagonised the potency of these folate-like inhibitors , as did thymidine in the case of the TS inhibitors raltitrexed and pemetrexed.”