Possible Interaction: Folate and Vitamin C

“Numerous observational studies showed associations of antioxidants vitamins C and E) and folate intake with a reduced risk of cardiovascular disease, but randomized controlled clinical trials have generally not supported this hypothesis.”

“ Vitamin C further aids in iron absorption and folate metabolism.”

“Reduced folate absorption can occur in an environment of increased gastric juice pH and/or decreased ascorbic acid.”

“As documented by direct HPLC analysis and in concurrent assays with Lactobacillus casei, acidification provided by ascorbic acid can have dramatic effects on the measurement of RBC folates.”

“ Folate was stable for 14 days in cells when they were stored at 4 degrees … for seven days at -25 degrees C, but instability was increased by storage in ascorbic acid , by the use of stored (4 degrees C) ascorbic …, and by preparing the haemolysates by freeze-thaw cycling.”

“ Folate and AA deficiency lowered tissue folate and AA levels, respectively.”

“Possible interactions between folic acid folate ) and ascorbic acid (AA) have been suspected because megaloblastic anemia is occasionally observed in scorbutic patients, and it may or may not respond to folate treatment.”

“ConclusionBecause of the importance of folate in one-carbon metabolism, the potential influence of vitamin C intake on the time taken to deplete the liver folate store should be experimentally investigated.”

“These results indicate that there might be a collaborative relationship between vitamin C and folate regulation during sweet corn seed germination, while an inhibitive regulation might exist between vitamin C and E.”

“Retention of folate and ascorbic acid was affected by the same factors, and high content of ascorbic acid could provide a possible protection for folate degradation.”