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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Folate
drug:
Pralatrexate
Research Papers that Mention the Interaction
“Vitamin B12 and folate supplementation may allow for further dose escalation of pralatrexate and probenecid.”
A phase I clinical pharmacologic study of pralatrexate in combination with probenecid in adults with advanced solid tumors“After a 6 h exposure of HeLa cells to 0.5 μM pralatrexate , 80 % of intracellular drug was its active polyglutamate forms, predominantly the tetraglutamate, and was suppressed when cells were loaded with natural folates.”
“ Pralatrexate , a novel antifolate chemotherapeutic agent, was rationally designed to impede folate metabolism by inhibiting dihydrofolate reductase (DHFR) and to be more efficiently internalized into tumor cells.”
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