Possible Interaction: Folate and Pemetrexed

“ Folate receptor-&agr; facilitates uptake of pemetrexed.”

“ Folate biochemical pathway components such as FR-alpha are determinants of response to novel antifolate drugs such as pemetrexed.”

“&NA; The administration of pemetrexed requires routine supplementation with vitamin B12 and folate , even if blood concentrations are normal, in order to mitigate its hematologic toxicity.”

“ Pemetrexed is a chemotherapeutic agent that inhibits three enzymes involved in the folate pathway, all of which are involved in nucleotide synthesis.”

“ Pemetrexed is an anti-metabolite that targets multiple enzymes in folate pathway.”

“ Pemetrexed predominantly inhibits thymidylate synthetase and other folate enzymes, which are involved in the synthesis of purines and pyrimidines.”

“The plasma homocysteine level is associated with hematological toxicities in patients receiving pemetrexed with folate supplementation.”

“ Pemetrexed is inhibited by folate and its analogs, which are components of many culture media, making it challenging to study pemetrexed in vitro.”

“ Pemetrexed is an antifolate inhibiting different folate pathway genes (thymidylate synthase [TS], dihydrofolate reductase, glycinamide ribonucleotide formyltransferase [GARFT], and aminoimidazole carboxamide ribonucleotide formyltransferase, [AICARFT]).”

“BACKGROUND Pemetrexed inhibits three key folate enzymes: thymidylate synthetase (TYMS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT).”