Possible Interaction: Folate and Multivitamin Preparation

“Additional administration of vitamin supplements induced a further decrease in tHcy and an increase in folate.”

“Treatment with a daily multivitamin containing 1 mg folate significantly lowered tHcy levels in all patients by 19.2%.”

“…:Multivitamin treatment significantly increased (p<0.01, compared to placebo) plasma concentrations of … μmol/L), pyridoxal phosphate (55.1 to 75.2 nmol/L), folate (23 to 33 nmol/L), B12 (286 to 326 pmol/L)), C (… coefficient (1.23 to 1.15), but not vitamins A and thiamin.”

“In 54 women (… of NTDs, multivitamin supplementation containing … increased folate level (5.8 ± 0.9 to 19.2 ± 4.0 ng/mL, p < 0.0001) and decreased the homocysteine level (….8 nmol/mL, p < 0.0001) to minimize the risk of NTDs in all women, regardless of MTHFR genotype.”

“ Multivitamin supplementation with a high dose of folate prevents hyperhomocysteinemia after GBP.”

“Impact: This study suggests that multivitamin supplement use may modify the association between folate pathway genes and colorectal cancer risk in a post-folic-acid-supplemented population.”

“Proteinuria, higher TG and lower creatinine clearance were independently associated with higher homocysteine levels, while use of multivitamin with folate predicted lower homocysteine levels.”

“There was a trend towards a 63% lower mean number of falls in the MV ….3±0.1 falls vs 0.8±0.3 falls, P=0.078).Conclusions MV supplementation raised … and folate concentrations and increased serum 25(OH)D, which … an apparent positive effect on bone density.”

“ Black multivitamin users had higher concentrations of vitamin B6 (53.7 vs. 29.5 nmol/L; p < 0.001), B12 (427 vs. 372 pmol/L; p < 0.05) and folate (35.7 vs. 25.4 nmol/L; < 0.001) than non-users.”

“ Multivitamin users had mean intakes (from diet plus supplement) of folate above the RDA and iron intakes also increased to RDA levels among women aged 19 to 50 years.”