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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Folate and Doxorubicin Hydrochloride

Research Papers that Mention the Interaction

Ex vivo fluorescence imaging experiments and histological examination confirmed that folate modification can enhance the antitumorigenesis efficacy and reduce the cardiotoxicity of DOX.
Colloids and surfaces. B, Biointerfaces  •  2014  |  View Paper
Folate deprivation markedly increased growth inhibitory effects of the established MRP1 substrates daunorubicin (~twofold), doxorubicin (~fivefold), and methotrexate (~83-fold) in MRP1-overexpressing cells, proportional to MRP1 expression.
Cancer Chemotherapy and Pharmacology  •  2014  |  View Paper
The released behavior of Dox can be significantly enhanced at endosomal pH compared to physiological pH. After folate modification, nanoparticles can lead to more cellular endocytosis.
International journal of pharmaceutics  •  2017  |  View Paper