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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Flutamide
supplement:
Progesterone
Research Papers that Mention the Interaction
“ Flutamide counteracted the suppressive effects of the progesterone antagonists on endometrial wet weight, thickness, stromal compaction, and mitotic index.”
A role for the androgen receptor in the endometrial antiproliferative effects of progesterone antagonists“After 4, 5, and 6 h, progesterone substantially suppressed the mating recognition ability of males, where the density of each group was extremely low at 6 h. Flutamide had a similar effect on the mating recognition ability of male rotifers as that of progesterone.”
“The fertilization rate of male rotifers was suppressed by both progesterone and flutamide (P < 0.05), and higher drug concentrations had stronger suppressive effects.”
Fertilization and male fertility in the rotifer Brachionus calyciflorus in the presence of three environmental endocrines.“ Flutamide also blocked progesterone and triamcinolone acetonide induced gonadotropin surges and ovulation in PMSG-primed immature female rats.”
“ Progesterone (0.8 mg/kg body wt) was incapable of overcoming this suppressive effect of flutamide.”
“Intra-ovarian Silastic implants containing the antiandrogen, Flutamide , or its active metabolite, reduced the level of progesterone secretion in porcine granulosa cell cultures by approximately 50%.”
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