Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 4 months ago

Possible Interaction: Flutamide and Progesterone

supplement:

Progesterone

Research Papers that Mention the Interaction

After 4, 5, and 6 h, progesterone substantially suppressed the mating recognition ability of males, where the density of each group was extremely low at 6 h. Flutamide had a similar effect on the mating recognition ability of male rotifers as that of progesterone.
The fertilization rate of male rotifers was suppressed by both progesterone and flutamide (P < 0.05), and higher drug concentrations had stronger suppressive effects.
Chemosphere  •  2019  |  View Paper
In luteal tissues, Cx43 and 3β-HSD expression and progesterone concentration decreased (P < 0.01) after postnatal flutamide treatment.
Domestic animal endocrinology  •  2011  |  View Paper
Flutamide also blocked progesterone and triamcinolone acetonide induced gonadotropin surges and ovulation in PMSG-primed immature female rats.
Progesterone (0.8 mg/kg body wt) was incapable of overcoming this suppressive effect of flutamide.
Journal of steroid biochemistry  •  1990  |  View Paper
The marked increase in tissue T content coupled to … of tumor growth induced by 4-OH-A. Flutamide , on the other hand, …, 17-OH Preg, P , and 17-OH P, with no significant change in the concentration of … fall in tissue P levels in the inhibition of tumor growth.
Breast Cancer Research and Treatment  •  1988  |  View Paper
Intra-ovarian Silastic implants containing the antiandrogen, Flutamide , or its active metabolite, reduced the level of progesterone secretion in porcine granulosa cell cultures by approximately 50%.
Endocrinology  •  1978  |  View Paper