supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Flurazepam
supplement:
Gamma-Aminobutyric Acid
Research Papers that Mention the Interaction
“Chronic … to flurazepam produced a concentration- (EC50, approximately 1.1 microM after a 48-hr exposure) and time-… (t1/2, approximately 3 hr at 100 microM) reduction in the efficacy (Emax) of GABA to enhance [3H]flunitrazepam binding to BzR, a characteristic of uncoupling in native GABAA receptor isoforms.”
Chronic exposure to benzodiazepine receptor ligands uncouples the gamma-aminobutyric acid type A receptor in WSS-1 cells.“In this study, we measured the effects of individually mutating 22 residues throughout the BZD binding pocket on the abilities of eszopiclone, zolpidem, and flurazepam to potentiate IGABA.”
Different Residues in the GABAA Receptor Benzodiazepine Binding Pocket Mediate Benzodiazepine Efficacy and Binding“Using whole cell patch-clamp recordings from pyramidal cells acutely dissociated from rat hippocampal slices, Ro-15 1788 (…) was shown to enhance the GABAA-receptor mediated currents evoked by application of γ-aminobutyric acid GABA ) and to antagonize the enhancing … of the benzodiazepine agonist flurazepam (FZP) on … GABAA response.”
“When GABA or nipecotic acid (a GABA uptake blocker) were added with flurazepam during chronic drug exposure, neuronal responses to GABA were significantly less sensitive to modulation by 0.5 microM flurazepam compared to flurazepam treatment alone.”
“Since muscimol and THIP are not subject to uptake, there may be increased uptake of GABA after 1 week of FZP treatment, though it may not persist during continued treatment.”
“Application of GABA, nipecotic acid (GABA uptake inhibitor) and a benzodiazepine flurazepam ), which enhances the action of GABA , increased the duration and intensity of ipsilateral inhibition and response pause, while bicuculline blocked these acoustically-evoked inhibitory events.”
“BZ-receptor agonists such as flunitrazepam, diazepam, clonazepam and flurazepam enhanced the effect of submaximal concentrations of GABA (10 microM)-stimulated 36Cl influx.”
“These results suggest that the inhibitory effect of flurazepam on the release of 5-HT is mediated by benzodiazepine/GABAA receptors in the hippocampus and that GABA exerts a tonic inhibitory effect on the release of 5-HT in the region of the brain.”
“Iontophoresis of flurazepam augmented spontaneous IPSPs and increased the hyperpolarization induced by GABA.”
“The inhibitory effect of GABA is enhanced by the simultaneous application of nipecotic acid or flurazepam.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback