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Possible Interaction: Flurazepam and Gamma-Aminobutyric Acid

Research Papers that Mention the Interaction

Chronic … to flurazepam produced a concentration- (EC50, approximately 1.1 microM after a 48-hr exposure) and time-… (t1/2, approximately 3 hr at 100 microM) reduction in the efficacy (Emax) of GABA to enhance [3H]flunitrazepam binding to BzR, a characteristic of uncoupling in native GABAA receptor isoforms.
Molecular pharmacology  •  1994  |  View Paper
In contrast, at saturating GABA concentrations, flurazepam reduced current amplitudes at both pH 7.2 and 6.0.
The slowing of deactivation kinetics by flurazepam decreased with GABA concentration, but at pH 6.0, this trend was shifted toward a higher GABA concentration.
British journal of pharmacology  •  2008  |  View Paper
Using whole cell patch-clamp recordings from pyramidal cells acutely dissociated from rat hippocampal slices, Ro-15 1788 (…) was shown to enhance the GABAA-receptor mediated currents evoked by application of γ-aminobutyric acid GABA ) and to antagonize the enhancing … of the benzodiazepine agonist flurazepam (FZP) on … GABAA response.
Neurochemical Research  •  2004  |  View Paper
Flurazepam potentiated the depressant effect of GABA (2.5 and 5 mM) on the b- and d-wave amplitude.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP  •  2003  |  View Paper
When GABA or nipecotic acid (a GABA uptake blocker) were added with flurazepam during chronic drug exposure, neuronal responses to GABA were significantly less sensitive to modulation by 0.5 microM flurazepam compared to flurazepam treatment alone.
Brain Research  •  1992  |  View Paper
Since muscimol and THIP are not subject to uptake, there may be increased uptake of GABA after 1 week of FZP treatment, though it may not persist during continued treatment.
Pharmacology Biochemistry and Behavior  •  1991  |  View Paper
Application of GABA, nipecotic acid (GABA uptake inhibitor) and a benzodiazepine flurazepam ), which enhances the action of GABA , increased the duration and intensity of ipsilateral inhibition and response pause, while bicuculline blocked these acoustically-evoked inhibitory events.
Hearing Research  •  1991  |  View Paper
BZ-receptor agonists such as flunitrazepam, diazepam, clonazepam and flurazepam enhanced the effect of submaximal concentrations of GABA (10 microM)-stimulated 36Cl influx.
The Journal of pharmacology and experimental therapeutics  •  1989  |  View Paper
These results suggest that the inhibitory effect of flurazepam on the release of 5-HT is mediated by benzodiazepine/GABAA receptors in the hippocampus and that GABA exerts a tonic inhibitory effect on the release of 5-HT in the region of the brain.
Neuropharmacology  •  1989  |  View Paper
Iontophoresis of flurazepam augmented spontaneous IPSPs and increased the hyperpolarization induced by GABA.
Neuroscience Letters  •  1989  |  View Paper
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