Possible Interaction: Fluoxetine and Vitamin C

“Patients treated … months with fluoxetine … vitamin C showed a significant decrease in depressive symptoms in comparison to the fluoxetine plus placebo group as measured by the CDRS (t=….36, P<0.0001) and CDI (t=12.27, P<0.0001), but not CGI (t=0.13, P=0.90).”

“Co-treatment with fluoxetine and vitamin C also significantly inhibited the expression and activation of MMP-9 at 8 h and 1 d … h, 8 h or 24 h after injury) were significantly inhibited by co-treatment with fluoxetine and vitamin C. Furthermore, the combination of fluoxetine … vitamin C ….”

“These results demonstrate the synergistic effect combination of low-dose fluoxetine and vitamin C on BSCB disruption after SCI and furthermore support the effectiveness of the combination treatment regimen for the management of acute SCI.”

“ Fluoxetine and ascorbic acid without simvastatin only produced ~50% of recovery produced by the 3-drug combination.”

“ Fluoxetine combined with simvastatin and ascorbic acid produced a 19-fold increase in neurogenesis versus controls in healthy rats; fluoxetine alone produced 10-fold increase.”

“Sub-effective dose of ascorbic acid combined with sub-effective doses of fluoxetine , imipramine, bupropion, MK-801 or 7-nitroindazole produced a synergistic antidepressant-like effect in mice exposed or not to TNF-α.”