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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Fluoxetine
supplement:
St John's Wort
Research Papers that Mention the Interaction
“ TheHypericum extract achieved 83% of the efficacy of fluoxetine on the HAMD and 78% on the DS.”
Hypericum perforatum versus fluoxetine in the treatment of mild to moderate depression“Although these interactions are often predictable, the use of fluoxetine , paroxetine and Hypericum extract should be avoided in cancer patients.”
“As CYP3A4 is an important metabolic pathway for all DOACs except dabigatran, it appears reasonable to recommend avoiding the co-prescription of fluoxetine and fluvoxamine (weak to moderate CYP3A4 inhibitors) and St John’s wort (CYP3A4 inducer).”
“Thus, the potency of various St. John's wort extracts for inhibiting the neuronal uptake of serotonin, a characteristic of conventional antidepressants such as fluoxetine , increases with increasing hyperforin content.”
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