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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Fluoxetine
supplement:
Oxytocin
Research Papers that Mention the Interaction
“Chronic treatment with fluoxetine and paroxetine desensitizes 5-HT(1A) receptors on oxytocin neurons, and that might in part determine the onset of delayed ejaculation.”
Oxytocin involvement in SSRI-induced delayed ejaculation: a review of animal studies.“ Fluoxetine decreased the oxytocin response at 15 but not at 30 min post-DOI injection, and potentiated the ACTH and corticosterone responses at 30 min post-DOI injection.”
“Overall, these results indicate that chronic fluoxetine treatment can potentiate 5-HT2A receptor signaling in frontal cortex but differentially alters 5-HT2A receptor signaling in oxytocin-containing neurons and corticotropin-releasing factor-containing neurons in the paraventricular nucleus.”
“In vehicle-pretreated rats, fluoxetine produced a dose-dependent reduction in the (±)8-OH-DPAT-induced increase in plasma ACTH and oxytocin levels.”
“During further withdrawal from fluoxetine , there was a gradual increase in the oxytocin response toward control levels.”
“However, even 60 days after discontinuation of fluoxetine , the oxytocin response was still significantly reduced by 26% compared with controls.”
“Long-term exposure to fluoxetine produces a desensitization of hypothalamic postsynaptic 5-hydroxytryptamine (5-HT)1A receptors, indicated by a substantial inhibition of the 5-HT1A receptor-mediated stimulation of oxytocin and adrenocorticotropic hormone (ACTH) secretion.”
“The oxytocin response to MTA and MMAI was inhibited by fluoxetine.”
“Chronic injections of fluoxetine inhibited the ACTH, corticosterone and oxytocin responses to 8-OH-DPAT, suggesting reduced 5-HT1A receptor function.”
“ Fluoxetine and DMI potentiated the MK-212- and DOI-induced increase of plasma oxytocin levels and potentiated the effect of DOI on plasma adrenocorticotropic hormone (corticotropin) and prolactin levels.”
“These findings suggest that oxytocin is causally involved in FLX + EE mediated remediation of postpartum stress-related behaviors, and HPA axis function in postpartum dams.”
The combination of fluoxetine and environmental enrichment reduces postpartum stress-related behaviors through the oxytocinergic system and HPA axis in mice“ FLX exposure decreased oxytocin receptor binding in the nucleus accumbens core and central amygdala, and vasopressin 1a receptor binding in the medial amygdala.”
“However, the oxytocin levels were significantly lower in the fluoxetine group than in the citalopram group (p = 0.05).”
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