Possible Interaction: Fluoxetine and Melatonin

“One of the hypothesis assumes, that fluoxetine increases indirectly melatonin production.”

“Using melatonin (3 mg or 5 mg/day) in combination with 20 mg/day fluoxetine resulted in significant reduction in both total and different components of FIQ score compared to the pretreatment values.”

“RESULTS Fl oxetine si gnificantly reduced mel atonin le vels in both groups.”

“However, combined treatment with fluoxetine and melatonin at the selected dose attenuated stress-induced behavioral abnormalities.”

“Our findings suggest that combined fluoxetine and melatonin treatment exerts synergistic antidepressant effects possibly by restoring hippocampal BDNF–TrkB signaling.”

“ Melatonin reduced the increased lipid peroxidation and transaminase activity in rats received fluoxetine (p<0.05).”

“Rats received melatonin in combination with fluoxetine showed a reduction in the severity of degeneration and inflammatory changes in different tissues, brain, heart, liver, lungs, testes and kidneys as compared to the fluoxetine group.”

“Therefore, melatonin fundamentally reversed the side effects of fluoxetine in the rat model which is comparable to human medicine.”

“We also showed the potency of fluoxetine in inducing leukopenia, thrombocytopenia and hypochromic and macrocytic anemia which was blunted by melatonin.”

“Furthermore, animals receiving fluoxetine plus early-photophase melatonin also showed signs of gonadal regression.”

“The anti-oedema effects of fluoxetine and melatonin or the tricyclic antidepressant imipramine were additive.”

“Compared to the effects of 10 mg/kg of fluoxetine , which completely prevented CMS-induced dysregulation of behaviour, melatonin was less effective.”

“Exogenous melatonin (0.25mg/kg/day) for 8 days counteracted the inhibitory effects of both desipramine and fluoxetine at concentrations of 2.5mg/kg/day.”

“We conclude that chronic fluoxetine treatment increases daytime plasma melatonin and pineal AA-NAT gene expression despite downregulated pineal cAMP signaling in the rodent.”