Possible Interaction: Fluoxetine and Glutathione

“In addition, chronic treatment with other mood stabilizing drugs lamotrigine and carbamazepine, but not antidepressants desipramine and fluoxetine , increased both glutathione levels and the expression of glutamate-cysteine ligase in SH-SY5Y cells.”

“Furthermore, the combined treatment of sub-effective doses of GSH (100 nmol/site, icv) with a sub-effective dose of classical antidepressants ( fluoxetine 10 mg/kg, and imipramine 5 mg/kg, ip) presented synergistic effect by decreasing the immobility time in the FST.”

“The intracellular ROS level and GSH level were significantly modulated (P < 0.05) in response to fluoxetine and sertraline.”

“ FLX decreased CK, CK-MB, lipid hydroperoxide, thiobarbituric acid reactive substances, and pro-oxidant/anti-oxidant balance levels while increasing superoxide dismutase activity, glutathione , and ferric reducing/anti-oxidant power levels.”

“ Fluoxetine at 10 mg/kg significantly reversed the reduced glutathione ( GSH ) level, the ratio of GSH/oxidized glutathione, and the reactive oxygen species level in rat lungs from the MA group.”

“In conclusion, prefrontal cortical GSH depletion and the proinflammatory response underlying depressive- and anxiety-like states induced by CSIS were prevented by FLX.”

“Both desipramine and fluoxetine , at either dose, significantly increased GSH in colonic tissue.”

“Reduced glutathione increased after sertraline, fluvoxamine and the lower dose of fluoxetine or imipramine.”