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“Compared to placebo, fluoxetine increased glucose disposal (M) by 2.4-fold (P<0.05), the insulin sensitivity index (M/I) by 2.7-fold (P<0.03) and the glucose metabolic clearance rate (MCR) by 2.9-fold (P<0.03).”
International Journal of Obesity • 1997 | View Paper
“The results of the present study revealed that fluoxetine may regulate glucose and lipid metabolism via the PI3K-AKT signaling pathway in diabetic rats.”
“In conclusion, fluoxetine downregulated hepatic G6Pase expression, subsequently enhanced the transformation of glucose to lipid, and ultimately resulted in hepatic steatosis, but with no impact on fatty acid uptake.”