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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Fluoxetine
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“ Fluoxetine tended to decrease serum corticosterone and significantly (p < 0.05) decreased serum ACTH while BEO had no effect on these two stress hormones.”
“ Fluoxetine decreased the oxytocin response at 15 but not at 30 min post-DOI injection, and potentiated the ACTH and corticosterone responses at 30 min post-DOI injection.”
“Treatment with fluoxetine for 21 or 42 days produced diminished adrenocorticotropic hormone (ACTH) and oxytocin (but not corticosterone) responses to DOI injections (2.5 mg/kg i.p.;”
“Increased neuronal 5‐HT content induced by systemic administration of the …‐hydroxytryptophan (5‐HTP) in combination with the 5‐HT reuptake inhibitor fluoxetine raised CRH mRNA expression in the paraventricular nucleus (PVN) by 64%, increased … (POMC) mRNA in the anterior pituitary lobe by 17% and stimulated ACTH secretion …‐fold.”
Serotonergic Stimulation of Corticotropin‐Releasing Hormone and Pro‐Opiomelanocortin Gene Expression“Administration of serotonin (… reuptake inhibitor fluoxetine (Flx), or of the 5‐HT agonists 8‐OH‐DPAT (5‐HT1A), 5‐carboxamido‐tryptamine (5‐HT1A+1B+5A+7), RU …‐methyl‐5‐HT (5‐HT2A+2B+2C), MK212 (5‐HT2B+2C), or methyl‐chlorophenyl‐piperazine (5‐HT2A+2C) dose‐dependently stimulated ACTH ….”
“ Fluoxetine treatment caused lower levels of ACTH , but not of corticosterone secretion, in response to immobilization stress.”
“Long-term exposure to fluoxetine produces a desensitization of hypothalamic postsynaptic 5-hydroxytryptamine (5-HT)1A receptors, indicated by a substantial inhibition of the 5-HT1A receptor-mediated stimulation of oxytocin and adrenocorticotropic hormone (ACTH) secretion.”
“Pretreatment of rats with fluoxetine blocked the ACTH response to MBDB and MMAI, but not to MTA.”
“Chronic injections of fluoxetine inhibited the ACTH , corticosterone and oxytocin responses to 8-OH-DPAT, suggesting reduced 5-HT1A receptor function.”
“ Fluoxetine caused a significant increase in ACTH and AVP concentrations in peripheral plasma as well as a significant increase in CRF and AVP concentrations in hypophysial portal plasma.”
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