Possible Interaction: Fluorouracil and Tretinoin

“ ATRA plus fluorouracil treatment reduced the viability more strongly than either drug alone, indicating an additive effect.”

“Furthermore, there was an indication that the combination of ATRA with 5FU and CDDP caused an increase in cell cycle arrest in G2/M and G0/G1.”

“We conclude that low concentration of ATRA enhances the cytotoxicity of CDDP and 5FU by facilitating apoptosis and cell cycle arrest in gastrointestinal CSCs and provide a rational basis for the design of novel, well-tolerated CDDP- and 5FU-based chemotherapy in human gastrointestinal carcinoma.”

“The combination of ATRA and 5-Fu may enhance the chemotherapeutic efficacy.”

“The flow cytometry showed that the ATRA + 5-Fu group had a significantly higher apoptosis rate (76.9% ± 2.7%) than that in the ATRA group (38.2% ± 2.6%) and 5-Fu group (45.2% ± 2.3%) (P < 0.05).”

“The combination of ATRA and 5-FU or MMC promoted cell apoptosis, and the mechanism involved in apoptosis may be related to inhibition of survivin gene expression.”

“Viability of the cells decreased significantly after combined treatment with ATRA and 5-fluorouracil (5-FU) or mitomycin c (MMC) and was evaluated by fluorescence microscopy.”

“ Retinoid augmented the membrane permeability of anti-cancer drugs such as 5-FU , and reduced the exocytosis of anti-cancer drugs by suppressing the expression of the transport protein cMOAT.”

“ Retinoic acid , therefore, has an inhibitory effect on epithelial neoplasias, particularly in combination with 5-FU.”

“However, when fluorouracil is given concomitantly with vitamin A acid , then tumor regression is markedly enhanced depending on the concentration of both drugs.”

“Additionally, treatment of 5-FU combined with ATRA could increase miR-378c expression, whereas it decreased the expression of E2F7.”

“In conclusion, our study aims to confirm that ATRA enhances chemosensitivity to 5-FU of patients with CRC and expound the potential molecular mechanisms.”

“In this study, we utilized MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide), transwell assay, and flow cytometry to confirm that ATRA was able to enhance the inhibitory effects of 5-FU on HCT116 cells effectively by promoting cell apoptosis.”