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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Fluorouracil and Tretinoin

supplement:

Tretinoin

Research Papers that Mention the Interaction

It was concluded that daily application of 0.05% tretinoin cream appeared to enhance the efficacy of topical 5-FU in destruction of AK of the arms and may represent a useful treatment modality.
The British journal of dermatology  •  1987  |  View Paper
Furthermore, there was an indication that the combination of ATRA with 5FU and CDDP caused an increase in cell cycle arrest in G2/M and G0/G1.
We conclude that low concentration of ATRA enhances the cytotoxicity of CDDP and 5FU by facilitating apoptosis and cell cycle arrest in gastrointestinal CSCs and provide a rational basis for the design of novel, well-tolerated CDDP- and 5FU-based chemotherapy in human gastrointestinal carcinoma.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie  •  2015  |  View Paper
The combination of ATRA and 5-FU or MMC promoted cell apoptosis, and the mechanism involved in apoptosis may be related to inhibition of survivin gene expression.
Viability of the cells decreased significantly after combined treatment with ATRA and 5-fluorouracil (5-FU) or mitomycin c (MMC) and was evaluated by fluorescence microscopy.
Chinese medical journal  •  2008  |  View Paper
Both ATRA and 5-FU activated c-Jun N-terminal kinase (JNK) 1 and the combination of both agents resulted in additive or synergistic activation of JNK1, and also enhanced the induction of apoptosis.
Japanese journal of cancer research : Gann  •  2002  |  View Paper
Retinoid augmented the membrane permeability of anti-cancer drugs such as 5-FU , and reduced the exocytosis of anti-cancer drugs by suppressing the expression of the transport protein cMOAT.
Gan to kagaku ryoho. Cancer & chemotherapy  •  2001  |  View Paper
The damage induced with the RA + 5-FU mixture was more serious, but when the skin lesions relapsed they did so later and in a less severe way than the recurrences observed after treatment with RA alone.
Journal of cutaneous pathology  •  1981  |  View Paper
Retinoic acid , therefore, has an inhibitory effect on epithelial neoplasias, particularly in combination with 5-FU.
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete  •  1978  |  View Paper
RESULTS We investigated if pre-treatment with atRA enhanced the drug-sensitivity of various cancer cell lines to either 5-fluorouracil , adriamycin, or cisplatin.
RESULTS We investigated if pre-treatment with atRA enhanced the drug-sensitivity of various cancer cell lines to either 5-fluorouracil , adriamycin, or cisplatin.
Cancer research and treatment : official journal of Korean Cancer Association  •  2002  |  View Paper
ATRA plus fluorouracil treatment reduced the viability more strongly than either drug alone, indicating an additive effect.
PloS one  •  2017  |  View Paper