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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Fluorouracil
supplement:
Tangeretin
Research Papers that Mention the Interaction
“Collectively, results indicate that combination of TAN and 5-FU significantly accelerates apoptosis via JNK mediated pathway.”
“Several possible mechanistic pathways were screened, and found that co-exposure of TAN and 5-FU accelerates oxidative-stress and increases endogenous-ROS generation, which sequentially triggers the DNA damage response and activates the apoptotic pathway, by down-regulating autophagy and DNA repair system in HCT-116 cells.”
“ TAN and 5-FU co-treatment also remarkably reduces the mitochondrial membrane potential, and sequentially decreases ATPase activity.”
“Therefore, we investigate whether the combination of TAN with 5-FU increases their anticancer potential against colorectal cancer.”
Synergistic therapy with tangeretin and 5-fluorouracil accelerates the ROS/JNK mediated apoptotic pathway in human colorectal cancer cell.“Suppression of antiapoptotic gene products by PMF correlated with the enhancement of apoptosis induced by tumor necrosis factor-α and the chemotherapeutic agents cisplatin, paclitaxel, and 5-flurouracil.”
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