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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Fluorouracil and Tangeretin

supplement:

Tangeretin

Research Papers that Mention the Interaction

Collectively, results indicate that combination of TAN and 5-FU significantly accelerates apoptosis via JNK mediated pathway.
Several possible mechanistic pathways were screened, and found that co-exposure of TAN and 5-FU accelerates oxidative-stress and increases endogenous-ROS generation, which sequentially triggers the DNA damage response and activates the apoptotic pathway, by down-regulating autophagy and DNA repair system in HCT-116 cells.
TAN and 5-FU co-treatment also remarkably reduces the mitochondrial membrane potential, and sequentially decreases ATPase activity.
Therefore, we investigate whether the combination of TAN with 5-FU increases their anticancer potential against colorectal cancer.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association  •  2020  |  View Paper
Suppression of antiapoptotic gene products by PMF correlated with the enhancement of apoptosis induced by tumor necrosis factor-α and the chemotherapeutic agents cisplatin, paclitaxel, and 5-flurouracil.
Molecular Pharmacology  •  2011  |  View Paper