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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Fluorouracil
supplement:
Sulforaphane
Research Papers that Mention the Interaction
“Combining SF increased the cytotoxicity of CIS twofold and 5-FU tenfold, with no effects on non-cancerous stem cell viability and functions.”
“Conclusions Combining SF allowed lower doses of CIS or 5-FU while enhancing these drug cytotoxicities against HNSCC–CSCs, with minimal effects on healthy cells.”
“We investigated whether SF could enhance the chemotherapeutic effects of cisplatin (CIS) and 5-fluorouracil (5-FU) against HNSCC–CSCs, and its mechanisms of action.”
Broccoli extract increases drug-mediated cytotoxicity towards cancer stem cells of head and neck squamous cell carcinoma“Studies of the interaction mechanism have revealed that sulforaphane and 5-fluorouracil act synergistically in the MDA-MB-231 cells by inducing autophagic cell death and premature senescence.”
“ Sulforaphane and 5-fluorouracil have been shown to interact synergistically in the breast cancerMDA-MB-231 cell line, resulting in a significant reduction of the number of live cells compared to alone treatments.”
“In conclusion, combining SF with low doses of CIS or 5-FU increased cytotoxicity against SCCHN cells, while having minimal effects on normal cells.”
“Our results demonstrate synergism between SFN and 5‐Fu at higher doses against the ACC‐M and ACC‐2 cells, which was associated with the decreased expression of nuclear NF‐κB p65 protein.”
“Treatment ACCs cells with SFN and 5‐Fu in combination, led to synergistic inhibition on cell growth and a decreased expression in nuclear NF‐κB p65 protein.”
“Although cisplatin (CIS), gemcitabine (GEM), doxorubicin, 5-flurouracil , or SF effectively induced apoptosis and prevented viability, combination of a drug with SF increased toxicity.”
Sulforaphane increases drug-mediated cytotoxicity toward cancer stem-like cells of pancreas and prostate.
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