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Last Updated: 4 months ago

Possible Interaction: Fluorouracil and Resveratrol

supplement:

Resveratrol

Research Papers that Mention the Interaction

Methods: We investigated whether resveratrol modulates the effects of 5-Fluorouracil (5-FU) and TNF-β on the malignant potential of human colorectal cancer (CRC) cells (HCT116) and their corresponding isogenic 5-FU-chemoresistant derived clones (HCT116R) in 3D-alginate tumor microenvironment.
Nutrients  •  2018  |  View Paper
Our results demonstrate that resveratrol can potentiate the anti-tumor effects of 5-FU on CRC cells by chemosensitizing them, inhibiting an EMT phenotype via up-regulation of intercellular junctions and by down-regulation of NF-κB pathway.
Resveratrol blocked the proliferation of all four CRC cell lines and synergized the invasion inhibitory effects of 5-FU.
Biochemical pharmacology  •  2015  |  View Paper
Further, gene expression studies showed that the combination of resveratrol and 5-fluorouracil exhibited different effects on different genes that may influence the net antagonistic effect.
BioMed research international  •  2014  |  View Paper
Importantly, the combination treatment with RES and 5-FU induced a remarkably synergistic enhancement of growth inhibition and apoptosis through the additional suppression of the MAPK/Erk1/2 signaling pathway in colon cancer DLD-1 cells.
The Journal of nutritional biochemistry  •  2013  |  View Paper
Data obtained showed additional effects of RSV to 5-FU treatments on the increase ofapoptotic events, and suggested alternative approaches to obtain a stronger antitumor response, and diminished side-effects when low concentrations of anti-cancer drugs are used.
Roumanian archives of microbiology and immunology  •  2013  |  View Paper
A significant inhibition of cell proliferation, migration, and increased apoptosis were observed when moderate concentration of Res (15 microM) was associated with very low concentration of 5-FU (0.5 microM).
Oncology research  •  2011  |  View Paper
Since combined treatment using 5-FU with resveratrol resulted in a significant decrease in long-term cell survival, we investigated the possible basis of this synergistic interaction at a molecular level, focusing on oxidative stress as a possible mediator of cell death.
Cellular Physiology and Biochemistry  •  2011  |  View Paper
Cancer cells with centrosome amplification, either spontaneous or 5-fluorouracil-induced , were more sensitive to apoptosis induction by resveratrol.
Cancer letters  •  2010  |  View Paper
Moreover, G(1)-arrest of the p53+/+ cells was elicited by lower doses of RSV and 5-FU in combination, but not with either agent alone.
RSV (200 microM) interacted with 5-FU in a synergistic manner (mean CI < 0.9).
Cancer biology & therapy  •  2008  |  View Paper
RESULTS Resveratrol inhibited the growth of hepatoma cells line H22 in a dose- and time-… H22 cells was 6.57mg x L(-1),The synergistic anti-tumor effects of resveratrol … 5-FU increased to a greater extent than for H22 … (70.2% vs 28.4%) P<0.05 .Under
RESULTS Resveratrol inhibited the growth of hepatoma cells line … x L(-1),The synergistic anti-tumor effects of resveratrol … 5-FU increased to a greater extent than for H22 cells treated with 5-FU alone (… typical apoptotic bodies were commonly found in tumor cells in the drug-treated groups.
World journal of gastroenterology  •  2002  |  View Paper
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