Possible Interaction: Fluorouracil and Quercetin

“Similar anti-apoptotic effects were observed when Quercetin was combined with other anti-neoplastic agents: Taxol, Pirarubicin and 5-Fluorouracil (5-Fu).”

“In some cell lines, treatment with quercetin and 5-FU caused an additional or synergistic effect.”

“Moreover, AGS-cyr61 cells treated with quercetin concentrations close to the IC50 and simultaneously treated with 5-FU or ADR in the sub-lethal range showed strong synergism between quercetin and these two drugs.”

“In p53-null cells, the combination of low dose 5-FU with up to 6 μM quercetin promoted clonogenic survival.”

“Treatment with 5-FU resulted in anemia at both 5 days and 14 days; however, quercetin blocked this effect at 14 days (P < .001).”

“It seems that the use of QRC can improve the treatment process of oral mucositis induced by 5-FU.”

“The results indicated that quercetin , luteolin and combinations of these compounds with 5-FU inhibited the growth of HT 29 cells.”

“The combination of 5-FU and Quer compared to 5-FU alone improved apoptosis by increasing the gene expression of Bax and p53 and caspase-9 activity and decreasing the Bcl2 gene expression.”

“The results of our study demonstrated that quercetin in combination with 5-FU significantly inhibited growth (P<0.05) and stimulated apoptosis (P<0.005) in EC9706 and Eca109 esophageal cancer cells compared with quercetin or 5-FU alone.”

“In the MTT assay, but not in the clonogenic assay, a synergistic interaction between quercetin and 5-FU was found for COLO 320 DM cells.”

“Our results therefore indicate that this interaction between quercetin and 5-FU mainly takes place at the level of growth inhibition.”