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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Fluorouracil
supplement:
Polyunsaturated Fatty Acids
Research Papers that Mention the Interaction
“It has been shown that long-chain n-3 polyunsaturated fatty acids (n-3 PUFAs ) could act synergistically with 5-fluorouracil (5-FU) to kill cancer cells.”
Antitumor Effect of 5-Fluorouracil-Loaded Liposomes Containing n-3 Polyunsaturated Fatty Acids in Two Different Colorectal Cancer Cell Lines“Conclusions Based on the results of the present study, it is concluded that PUFAs enhance the tumoricidal action of the anti-cancer drug 5-FU by acting on anti-angiogenic factors and enzymes involved in lipid metabolism.”
“Results It was … combined treatment of 5-FU + PUFAs on gastric carcinoma (MGC and SGC) cells produced a significant growth inhibitory action compared with either agent alone by inhibiting … production of TNF-α and VEGF and a simultaneous increase in the expression of LPL, PPAR-γ, and C/EBP.”
Polyunsaturated fatty acids augment tumoricidal action of 5-fluorouracil on gastric cancer cells by their action on vascular endothelial growth factor, tumor necrosis factor-α and lipid metabolism related factors
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