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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Fluorouracil and Paricalcitol

supplement:

Paricalcitol

Research Papers that Mention the Interaction

Compared with their individual therapy, combination of 5-FU and paricalcitol showed more significant reducing effect on numbers of grown tumors and large aberrant crypts foci.
Herein, we investigated whether paricalcitol , a synthetic vitamin D analogue with potential antitumor properties, would enhance the chemopreventive efficacy of 5-FU on an intermediate-term (15 weeks) model of colorectal tumors induced by azoxymethane (AOM) in rats.
Our findings suggest that combined use of paricalcitol with 5-FU exhibits an augmenting chemopreventive effect against colorectal tumors, and might potentially be useful for chemoprevention in colorectal cancer patients.
Cancer Prevention Research  •  2016  |  View Paper