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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Fluorouracil
supplement:
Orotic Acid
Research Papers that Mention the Interaction
“The 5-bromo, 5-chloro and 5-fluoro analogs of orotic acid were demonstrated to produce single or multiple blocking actions against this system.”
Biochemical screening of pyrimidine antimetabolites. III. The testing of drugs against a system with a non-oxidative energy source.“They are more effective than 5-fluorouracil in inhibiting incorporation of formate and orotic acid into RNA, thymidine into DNA, and phenylalanine into proteins.”
Potential anticancer agents. VI. 5-Substituted pyrimidine-6-carboxaldehydes.“Later, Bonner and Zeevaart (2) showed that 5-FU inhibited the incorporation of orotic acid into both RNA and DNA.”
“The inhibitory effect of 5-FU could be reversed by applying orotic acid at the same time as the application of 5-FU.”
Effects of 5-fluorouracil on photoperiodic induction and nucleic acid metabolism of xanthium.“ 5-Fluorouracil has been shown to interfere with the appearance of the elements of formic acid in the thymine component of nucleic …); it intervenes in the synthesis of ribonucleic acid, as evidenced by the blocking of the utilization of uracil or erotic acid as precursors of … to uridine (10).”
“Reversal of 5-FU inhibition by orotic acid suggests the hypothesis that the inhibition is related in some way to suppression of nucleic acid metabolism.”
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