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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Fluorouracil and Grape Seed Extract

Research Papers that Mention the Interaction

Grape seed extract (10-25 … of 5-Fluorouracil by 26% (P<0.05) in Caco-2 cells and was more potent than 5-Fluorouracil at 50-100 µg/mL. … new therapeutic option to decrease the symptoms of intestinal mucositis while concurrently impacting on the viability of colon cancer cells.
Grape seed extract (1000 mg/kg) increased jejunal crypt depth by 25% (P<0.05) in 5-Fluorouracil treated rats compared to 5-Fluorouracil controls, and attenuated the 5-Fluorouracil -induced reduction of mucosal thickness (25%, P<0.05).
PloS one  •  2014  |  View Paper
GSE partially protected IEC-6 cells from 5-FU-induced cytotoxicity and ameliorated intestinal damage induced by 5-FU in rats.
GSE prevented the decrease in IEC-6 cell viability induced by 5-FU (p < 0.01).
Cancer biology & therapy  •  2009  |  View Paper