supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 5 years ago
drug:
Fluorouracil
supplement:
Glucose
Research Papers that Mention the Interaction
“Notably, the inhibition rates of 5-fluorouracil on cells decreased over 48 h when treated with 4,500 and 9,000 mg/l glucose compared with 1,000 mg/l.”
High glucose promotes gastric cancer chemoresistance in vivo and in vitro“In the 1960s, researchers showed, in a series of in vitro experiments, that glucose increased the cytotoxicity of 5-fluorouracil.”
“Insulin releasing test indicated that the early phase insulin response to glucose load was significantly diminished in animals treated with 5-FU at day 2.”
[Impact of 5-fluorouracil on glucose metabolism and pancreatic pathology in rats].“Results indicated that 5-FU uptake by the tumor slices was not dependent upon pHi, but was enhanced by the presence of glucose.”
“A significant potentiation of the antitumor action of 5-fluorouracil in rats bearing the Flexner-Jobling carcinoma is produced by the intraperitoneal administration of large doses of glucose.”
Potentiation of 5-Fluorouracil Inhibition of Flexner-Jobling Carcinoma by Glucose
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback