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Last Updated: 4 months ago

Possible Interaction: Fluorouracil and Ginseng

supplement:

Ginseng

Research Papers that Mention the Interaction

Cell growth decreased more with the combined treatment of 5-FU and AGBE than with 5-FU or AGBE applied alone, suggesting that AGBE can reduce the dose of 5-FU needed to achieve desired effects and thereby decrease the dose-related toxicity of the chemotherapy agent.
The assay of combined treatment groups indicated that AGBE can heighten the arrest of SW-480 cells in the S phase induced by 5-FU , and increase the cell distribution in G2/M phase compared with 5-FU applied alone.
The enhancement of S and G2/M phase arrest, rather than cell apoptosis, should be the mechanism of synergistic effects of AGBE on 5-FU.
Oncology reports  •  2009  |  View Paper
WG at 0.2 mg/mL did not show obvious synergy with 5-FU co-treatment, while RG at 0.2 and 0.3 mg/mL significantly enhanced the anti-proliferative effects of 5-FU at concentrations of 10, 50 and 100 μM (P < 0.05).
Archives of pharmacal research  •  2009  |  View Paper
Some increase in AUC was observed in 5-FU plus ginseng group ; however, the difference did not reach statistical significance compared with 5-FU alone.
Biomedical chromatography : BMC  •  2015  |  View Paper
Moreover, PGS had a synergistic cytotoxic effect with 5-FU on human gastric cancer cells but not on normal gastric cells.
The American journal of Chinese medicine  •  2013  |  View Paper
Moreover, PGS had a synergistic cytotoxic effect with 5-FU on human gastric cancer cells but not on normal gastric cells.
The American journal of Chinese medicine  •  2013  |  View Paper