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“The combination of 5-FU and genistein significantly reduced final xenograft tumor volume when compared to 5-FU-alone by inducing apoptosis as well as autophagy.”
International journal of molecular sciences • 2014 | View Paper
“These results suggested that the combination of 5-FU and genistein exert a novel chemotherapeutic effect in colon cancers, and AMPK may be a novel regulatory molecule of COX-2 expression, further implying its involvement in cytotoxicity caused by genistein.”
“Under same conditions, the induction of Glut-1 by 5-FU was diminished by the combination treatment with 5-FU and genistein.”
Biochemical and biophysical research communications • 2005 | View Paper
“Treatment with genistein , a protein tyrosine kinase (PTK) inhibitor, inhibited the induction of ICAM-1 on NA cells by CDDP and 5-FU , whereas staurosporin, a protein kinase C inhibitor, did not.”
“In addition, we found that a KIF20A inhibitor, genistein , could enhance the antitumor activity of cisplatin and fluorouracil , which might be considered as a chemosensitive agent in GC.”