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Last Updated: 4 months ago

Possible Interaction: Fluorouracil and Genistein

supplement:

Genistein

Research Papers that Mention the Interaction

These results suggested that the combination of 5-FU and genistein exert a novel chemotherapeutic effect in colon cancers, and AMPK may be a novel regulatory molecule of COX-2 expression, further implying its involvement in cytotoxicity caused by genistein.
Under same conditions, the induction of Glut-1 by 5-FU was diminished by the combination treatment with 5-FU and genistein.
Biochemical and biophysical research communications  •  2005  |  View Paper
Treatment with genistein , a protein tyrosine kinase (PTK) inhibitor, inhibited the induction of ICAM-1 on NA cells by CDDP and 5-FU , whereas staurosporin, a protein kinase C inhibitor, did not.
British Journal of Cancer  •  1999  |  View Paper
In addition, we found that a KIF20A inhibitor, genistein , could enhance the antitumor activity of cisplatin and fluorouracil , which might be considered as a chemosensitive agent in GC.
In addition, we found that a KIF20A inhibitor, genistein , could enhance the antitumor activity of cisplatin and fluorouracil , which might be considered as a chemosensitive agent in GC.
Cancer management and research  •  2018  |  View Paper
CONCLUSION Genistein can potentiate the antitumor effect of 5-FU by inducing apoptotic as well as autophagic cell death.
CONCLUSION Genistein can potentiate the antitumor effect of 5-FU by inducing apoptotic as well as autophagic cell death.
MATERIALS AND METHODS To understand how genistein potentiates the antitumor effects of 5-FU , we examined apoptosis and autophagy in MIA PaCa-2 human pancreatic cancer cells and their derived xenografts.
MATERIALS AND METHODS To understand how genistein potentiates the antitumor effects of 5-FU , we examined apoptosis and autophagy in MIA PaCa-2 human pancreatic cancer cells and their derived xenografts.
The combination of 5-FU and genistein significantly reduced final xenograft tumor volume when compared to 5-FU-alone by inducing apoptosis as well as autophagy.
The combination of 5-FU and genistein significantly reduced final xenograft tumor volume when compared to 5-FU-alone by inducing apoptosis as well as autophagy.
Anticancer research  •  2014  |  View Paper
Treatment of gastric cancer cells with genistein reduced its chemoresistance to 5-Fu ( fluorouracil ) and ciplatin.
International journal of molecular sciences  •  2014  |  View Paper