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Last Updated: 4 months ago

Possible Interaction: Fluorouracil and Folic Acid

supplement:

Folic Acid

Research Papers that Mention the Interaction

Appropriate protocols on 5-fluorouracil monotherapy and on the modulation of the action of 5-fluorouracil by folic acid , are discussed.
Fortschritte der Medizin  •  1991  |  View Paper
Folic acid and methyltetrahydrofolate enhanced synthesis of Me-Cbl both in normal and in PA cells, while methotrexate and 5-fluorouracil depressed it.
Blood  •  1976  |  View Paper
Results indicate that folic acid appended SL bearing 5-FU are significantly (P < 0.01) active against primary tumor and metastasis than non-targeted sterically-SL.
Journal of drug targeting  •  2007  |  View Paper
Folic acid , because it can also potentially be metabolized to methylenetetrahydrofolate, was evaluated for its ability to potentiate FU antitumor activity in a dietary folic acid restricted murine model.
These results indicate that folic acid is a potent modulator of FU activity and could be considered as an alternative to leucovorin in the clinical setting.
While FU alone suppressed growth 25%, folic acid in combination with FU increased growth suppression to over 70%.
Biochemical pharmacology  •  1999  |  View Paper
Inhibition of thymidylate synthase, the enzyme involved in IdU dehalogenation, by 5-fluorouracil plus folic acid , or by novel inhibitors AG337 and ZD1694 led to a 3- to 5-fold increase in the 125IdU incorporation.
European journal of cancer  •  1996  |  View Paper
Pre-treatment with FA significantly improved the therapeutic efficacy of 5-FU , Ara-C and Mit-C; while MTX was more effective when given simultaneously with FA.
Chemotherapy  •  1984  |  View Paper