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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
drug:
Fluorouracil
supplement:
Folic Acid
Research Papers that Mention the Interaction
“The higher rate of response and the significantly prolonged survival time signify an improvement of the therapeutic profile of fluorouracil by addition of folic acid in the palliative therapy of colorectal carcinomas.”
[Fluorouracil as monotherapy or combined with folinic acid in the treatment of metastasizing colorectal carcinoma].“ FA supplementation and 5-FU significantly interacted to influence xenograft growth (P < 0.007).”
“Our data suggest that FA supplementation may be detrimental to 5-FU chemotherapy of colon cancer and pose public health concern.”
“Results indicate that folic acid appended SL bearing 5-FU are significantly (P < 0.01) active against primary tumor and metastasis than non-targeted sterically-SL.”
Design and development of folate appended liposomes for enhanced delivery of 5-FU to tumor cells“ Folic acid , because it can also potentially be metabolized to methylenetetrahydrofolate, was evaluated for its ability to potentiate FU antitumor activity in a dietary folic acid restricted murine model.”
“These results indicate that folic acid is a potent modulator of FU activity and could be considered as an alternative to leucovorin in the clinical setting.”
“While FU alone suppressed growth 25%, folic acid in combination with FU increased growth suppression to over 70%.”
“Pre-treatment with FA significantly improved the therapeutic efficacy of 5-FU , Ara-C and Mit-C; while MTX was more effective when given simultaneously with FA.”
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