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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Fluorouracil and Fat Emulsion

supplement:

Fat Emulsion

Research Papers that Mention the Interaction

Such changes were identified in 62.0 per cent … the effectiveness increased as the total dose of the 5-FU emulsion administered increased (50.9 per cent for 5,000 mg or less, 70.9 … 6,000 mg, and 72.7 per cent for 6,000 mg or more).
The Japanese journal of surgery  •  1978  |  View Paper
Furthermore, measurement of the concentration of 5-FU in the … 13 patients with gastric cancer who had been given the 5-FU emulsion or 5-FU in water orally 2 hours before surgery … 5-FU level was higher in the patients that received the emulsion than in … aqueous solution.
World Journal of Surgery  •  1978  |  View Paper
With 5-FU , the maximum concentration of drug in thoracic lymph and stomach was greater when administered as an emulsion than as an aqueous solution, and a high concentration persisted longer.
The Tohoku journal of experimental medicine  •  1977  |  View Paper
As to the relative concentration of these two forms of the drug, the oral administration of the 5-FU emulsion resulted in a maximum value 1.5 times higher than that of the 5-FU solution.
The Japanese journal of surgery  •  1978  |  View Paper
On the other side, the therapeutic efficiency of 10% 5-fluorouracil solution can be increased remarkably by preliminary treatment with HTH emulsion.
Dermatologica  •  1977  |  View Paper
A pronounced retardation of release of 5-FU and decrease of peak plasma concentration were also obtained following injection of these emulsions.
In addition, a local injection of 5-FU with emulsions was confirmed to be considerably advantageous from the viewpoint of metabolic inactivation.
Chemical & pharmaceutical bulletin  •  1977  |  View Paper