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Last Updated: 2 years ago

Possible Interaction: Fluorouracil and Epigallocatechin Gallate

Research Papers that Mention the Interaction

Moreover, EGCG enhanced the growth inhibitory effect of 5-FU and doxorubicin.
Archives of biochemistry and biophysics  •  2020  |  View Paper
Addition of EGCG increased the number of cells in the G2/M phase, while 5-FU arrested the cell cycle in phase S. Moreover, cell exposure to 5 Gy radiation decreased the effects of combining with EGCG.
CONCLUSIONS In summary, the combination of EG G an d 5-F U re duced both cell viability and migration as well as altered the cell cycle to a greater extent than 5-FU alone.
We evaluated whether the combination of lower doses of 5-FU with EGCG could be equally or more effective than the use of higher doses of 5-FU alone.
Archives of oral biology  •  2019  |  View Paper
CD studies indicated that there was an alteration in HSA secondary structure due to the binding of EGCG and FU.
It can be concluded that the combination of EGCG with FU may enhance anticancer efficacy.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy  •  2017  |  View Paper
Cell apoptosis rates in control group, 5-FU group, EGCG group and 5-FU combined with EGCG group …)%, (7.0±1.3)%, (6.0±1.2)% and (18.0±1.4)%, while apoptosis rate in 5-FU … EGCG group was significantly higher than those …=129.5, P=0.000).
In drug-resistant cells, the IC50 value of 5-FU combined with EGCG group obviously decreased compared with 5-FU group [(7.3±0.1) mg/L and (63.1±1.4) mg/L respectively, t=40.84, P=0.000], and the RI was 0.12.
Proliferation activity in drug-resistant cells was significantly decreased after EGCG treatment at different 5-FU concentrations (all P<0.05).
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery  •  2016  |  View Paper
Furthermore, we have found that reactive oxygen species (ROS) is an upstream signal of AMPK, and the combined treatment of EGCG and chemotherapeutic agents, 5-FU or Etoposide, exert a novel therapeutic effect on chemo-resistant colon cancer cells.
Cancer letters  •  2007  |  View Paper
Epigallocatechin-3-gallate increased the uptake of [(3)H]-thymidine and showed synergy with 5-fluorouracil , while its inhibitory action was strengthened after treatment with hypoxanthine, which indicates that epigallocatechin-3-gallate decreases the cellular production of nucleotides, thus, disturbing DNA and RNA synthesis.
The international journal of biochemistry & cell biology  •  2007  |  View Paper
EGCG at 0.1 microg/ml (a concentration found in serum after oral administration) markedly enhanced the growth-inhibitory effects of 5-fluorouracil.
Clinical cancer research : an official journal of the American Association for Cancer Research  •  2001  |  View Paper
Analogous studies were performed on 5FU-green tea extract mixtures, showing that 5FU leads to complexes not only with EGCG but also with other catechins.
Journal of mass spectrometry : JMS  •  2021  |  View Paper
Taken together, our data suggested that EGCG inhibits GC growth and reverses 5-FU resistance of GC through inactivation of TFAP2A/VEGF pathway and down-regulation of MDR-1 and P-gp expression.
Oncotarget  •  2017  |  View Paper